Research Article
Oncosuppressive Role of RUNX3 in Human Astrocytomas
Table 1
Associations between grade I-IV astrocytoma patients’ clinical data and RUNX3 gene molecular properties.
| | | Methylation | Protein expression | | Variable | Unmethylated % (n) | Methylated
% (n) |
(χ2; df)† | Low
% (n) | High
% (n) | |
| | Overall | 67.6 (92) | 32.4 (44) | | 48.6 (35) | 51.4 (37) | |
| | Grade | | | | | | | | I | 100 (14) | 0 (0) | <0.001
(49.3; 3) | 66.7 (4) | 33.3 (2) | 0.007 | | II | 88.6 (39) | 11.4 (5) | 25.9 (7) | 74.1 (20) | | III | 82.8 (24) | 17.2 (5) | 35.3 (6) | 64.7 (11) | | IV (GBM) | 30.6 (15) | 69.4 (34) | 81.8 (18) | 18.2 (4) |
| | Gender | | | | | | | | Male | 65.6 (40) | 34.4 (21) | 0.641
(0.22; 1) | 48.8 (20) | 51.2 (21) | 0.707♯ | | Female | 69.3 (52) | 30.7 (23) | 48.4 (15) | 51.6 (16) |
| | Age, years | | | | | | | | <50 | 88.7 (63) | 11.3 (8) | <0.001
(30.2; 1)) | 32.5 (13) | 67.5 (27) | 0.037♯ | | ≥50 | 44.6 (29) | 55.4 (36) | 68.8 (22) | 31.2 (10) |
| | Survival, months | | | | | | | | <24 | 40 (22) | 60 (33) | <0.001
(32.2; 1) | 80 (20) | 20 (5) | 0.001♯ | | ≥24 | 86.4 (70) | 13.6 (11) | 31.9 (15) | 68.1 (32) |
| | Methylation | | | | | | | | Unmethylated | | | | 39.2 (20) | 60.8 (31) | 0.026♯ | | Methylated | | | | 68.4 (13) | 31.6 (6) |
|
|
P-value estimated by Pearson Chi-square ( χ2) test. Kruskal-Wallis test. ♯Mann-Whitney U test. |
