The Role of Deubiquitinases in Oncovirus and Host Interactions

Table 4

Chemical DUB inhibitors.

DUB Inhibitors(DIs)	target	Cancer types	reference
HBX 41,108	USP5, 7, 8 and UCH-L3	myeloma	[50]
HBX -19,818	USP7	colon carcinoma	[51]
HBX-28,258	USP7	colon carcinoma	[51]
P5091	USP7	myeloma	[50]
P22077	USP7	-	[52]
GW7674	USP1	non-small cell lung cancer	[53, 54]
ML323	USP1 and some DUBs	non-small cell lung cancer and osteosarcoma	[53, 54]
b-AP15; (VLX1500)	UCHL5, USP14 and some DUBs	nonspecific	[55]
WPI 130	USP5/USP9x/USP14/UCHL1/UCHL5	breast cancer	[56, 57]
PR-619	broad-range DUB inhibitor	-	[52]