Immunotherapeutics in Multiple Myeloma: How Can Translational Mouse Models Help?

Table 1

Mouse models of multiple myeloma.

Model	Features
Xenograft models
SCID	Lack T and B lymphocytes
NOD/SCID	SCID + no circulating complement and low NK cell function
NSG	NOD/SCID + lack IL-2
(NOD/SCID/IL2R)
SCID-hu	SCID implanted with human fetal bone chips
SCID-rab	SCID implanted with rabbit bone chips
SCID-synth-hu	SCID implanted with 3D polymeric scaffolds coated with human BM stromal cells
Immunocompetent models
5T series	Syngeneic transplant of cell lines from spontaneously arising MM in aged C57BL/KaLwRij mice[188, 189]
	5T2MM	Moderate, progressive disease course
	5T33MM	Aggressive, rapidly progressive disease course
	5TGM1	Cell line derived from 5T33MM
Vk^*MYC	Transgenic: spontaneous AID-dependent activation of MYC in post germinal B cells[17]
	Transplant: syngeneic transplant of plasma cell lines from transgenic Vk^*MYC mice
Myc/Bcl-	Bitransgenic offspring of hemizygous Myc transgenic mice and hemizygous Bcl- mice[17]
XBP-1	Eμ-directed expression of XBP-1 spliced isoform, a factor governing plasma cell development that has been reported to frequently be overexpressed in human MM[18]
MOPC315.BM	Syngeneic transplant of plasmacytoma-resembling MM cells from granulomas in Balb/c mice injected intraperitoneally with mineral oil