Formation of Polyploid Giant Cancer Cells Involves in the Prognostic Value of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer

Table 6

Kaplan–Meier analysis of locally advanced rectal cancer patients treated with neoadjuvant chemoradiation (nCRT).

Variable	Mean Survival (months)	Chi-square		Survival analysis (Cox)
				B	OR	95% CI
Rest interval
≥60 days	46.35 ± 27.99	5.357	0.021	0.612	1.845	1.031–3.302	0.039
<60 days	61.39 ± 24.13
Pathological stage
Tis + T1 + T2	64.42 ± 22.53^■	7.553	0.006
T3	58.69 ± 24.61^□	30.120	0.001
T4	24.57 ± 24.61^▲	39.765	0.001
Duke’s stage
A + B	62.97 ± 21.60^△	13.527	0.001
C	52.69 ± 29.32^▼	7.415	0.006	0.409	1.505	1.174–1.930	0.001
D	28.65 ± 24.6^▽	38.719	0.001
nCRT
CR + PR + SD		7.773	0.005
PD
LN metastasis
No	63.45 ± 21.30	13.722	0.001
Yes	52.69 ± 29.32
Relapse and/or distant metastasis		66.532	0.001	1.839	6.293	3.591–11.027	0.001
No	62.21 ± 24.15
Yes	33.28 ± 21.18

^■Compared with T3; ^□compared with T4; ^▲compared with Tis + T1 + T2; ^△compared with C; ^▼compared with D; ^▽compared with A + B. OR, odds ratio; CI, confidence interval; nCRT, neoadjuvant chemoradiation therapy; CR, complete remission; PR, partial remission; PD, progressive disease; SD, stable disease; LN, lymph node; nCRT, neoadjuvant chemoradiation therapy.