A Comprehensive Evaluation of the Association between Polymorphisms in XRCC1, ERCC2, and XRCC3 and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis

Table 3

Meta-analysis of the association between XRCC1, ERCC2, and XRCC3 and overall survival for HCC patients.

Genetic comparisons	No. of; studies	Test of association	Model	Test of heterogeneity
		HR(95% CI)		P	I^2(%)
xrcc1 rs25487
AA vs. GG	5	0.97(0.51-1.87)	R	0.001	82.2
GA vs. GG	5	1.17(0.95-1.43)	F	0.121	45.2
AA+GA vs. GG	5	1.25(0.83-1.88)	R	0.002	76.3
xrcc1 rs1799782
TT vs. CC	3	0.72(0.48-1.08)	F	0.849	0
CT vs. CC	3	0.88(0.63-1.22)	F	0.853	0
ERCC2 rs13181
CC vs. AA	2	0.33(0.15-0.72)	F	0.884	0
CA vs. AA	2	0.83(0.62-1.12)	F	0.971	0
ERCC2 rs1799793
AA vs. GG	3	0.74(0.49-1.11)	F	0.840	0
GA vs. GG	3	0.93(0.67-1.28)	F	0.780	0
XRCC3 rs861539
CT vs. CC	2	1.64(1.11-2.42)	F	46.4	12

HR: hazard ratio; CI: confidence interval; vs: versus; F: fixed effect model; R: random effect model.