A Novel Biomarker Based on miRNA to Predict the Prognosis of Muscle-Invasive Bladder Urothelial Carcinoma

Table 2

Survival analysis for risk model with OS as endpoints in the TCGA dataset and validation dataset.

	TCGA dataset (N = 392)						Validation dataset (N = 62)
	Univariate			Adjusted^a			Univariate			Adjusted^b
Variable	HR	95% CI		HR	95% CI		HR	95% CI		HR	95% CI
Age	1.03	1.02–1.05	<0.001	1.02	1.01–1.04	0.009	1.07	1.02–1.11	0.002	1.06	1.02–1.11	0.005
Gender^c	0.88	0.63–1.24	0.463	0.84	0.6–1.18	0.311	—	—	—	—	—	—
Stage^d	1.8	1.47–2.21	<0.001	1.61	1.31–1.98	<0.001	—	—	—	—	—	—
Risk^e†	2.68	1.96–3.67	<0.001	2.03	1.47–2.83	<0.001	9.15	1.25–67.2	0.03	7.74	1.05–56.93	0.045

^aAdjusted for age, pathological stage, and gender. ^bAdjusted for age. ^cFemale (ref) vs. male. ^dStage II (ref) vs. stage III vs. stage IV. ^eHigh risk vs. low risk (ref). ^†Proportional risk assumptions were met.