Journal of Oncology / 2019 / Article / Fig 1

Review Article

Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma

Figure 1

Illustration of “Go or Grow” theory in malignant gliomas. Malignant gliomas often consist of two subpopulations of cells, which mutually interact and mutually change, that are characterized by uncontrolled-proliferation and by abnormal migration. One subpopulation of cells is rapidly proliferating and forming a stationary tumor mass, while the other subpopulation is actively migrating and moves into surrounding brain without cell division. Some of glioma cells in “Go” stage show characteristic morphological patterns of tumor cell migration, referred to as “secondary structures of Scherer.” These “secondary structures of Scherer,” which are also shown in Figure 2, have been classified into histological patterns: (i) perineuronal satellitosis, (ii) perivascular satellitosis, (iii) subpial spread, and (iv) invasion along the white matter tracts.