Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer

Figure 7

Live tumor area and number of metastatic lung nodules decreases with PNA treatment while survival increases with PNA treatment. (a) Subcutaneous 4T1 tumors are treated with HSA (control) or PNA. Tumors sections were stained by H&E and live tissue area was determined by stereology. (b) Tumor bearing mice were treated with or without PNA and after 3 weeks lungs were harvested for counting lung metastatic nodules. (c) 4T1 tumor bearing mice were treated with doxorubicin in the presence or absence of PNA. PNA combined with doxorubicin compared to doxorubicin alone significantly reduces lung metastasis, according to a paired two-tailed t test, p <0.05 ().

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