Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer

Figure 8

PNA treatment combined with chemotherapy reduces lung metastasis and enhances survival of mice carrying 4T1 tumors compared to chemotherapy treatment alone. (a) Tumor bearing mice were treated with a chemotherapy regimen, with and without PNA, and after 3 weeks lungs were harvested for counting metastatic lung nodules. PNA in the presence of chemotherapy significantly reduced lung metastases compared to chemotherapy alone, according to a paired two-tailed t test, p >0.01. (b) PNA combined with chemotherapy significantly increased overall survival of mice compared to chemotherapy alone, according to the Log-Rank (Mantel-Cox) test, with p value =.0013 ().

(a)

(b)