C-Reactive Protein to Prealbumin Ratio (CPR): A Novel Inflammatory-Nutritional Prognostic Factor for Predicting Cancer-Specific Survival (CSS) and Overall Survival (OS) in Patients with Resectable Esophageal Squamous Cell Carcinoma
Table 1
Comparison of baseline clinical characteristics based on CPR in ESCC.
Cases (n, %)
CPR
P-value
≤ 0.03 (n, %)
> 0.03 (n, %)
Age (years)
0.108
≤60
199 (57.5)
120 (54.3)
79 (63.2)
>60
147 (42.5)
101 (45.7)
46 (36.8)
Gender
0.077
Female
76 (22.0)
42 (19.0)
34 (27.2)
Male
270 (78.0)
179 (81.0)
91 (72.8)
Tumor length (cm)
0.242
≤ 3.0
96 (27.7)
66 (29.9)
30 (24.0)
> 3.0
250 (72.3)
155 (70.1)
95 (76.0)
Tumor location
0.179
Upper
18 (5.2)
11 (5.0)
7 (5.6)
Middle
164 (47.4)
97 (43.9)
67 (53.6)
Lower
164 (47.4)
113 (51.1)
51 (40.8)
Vessel invasion
0.025
Negative
289 (83.5)
192 (86.9)
97 (77.6)
Positive
57 (16.5)
29 (13.1)
28 (22.4)
Differentiation
0.750
Well
47 (13.6)
32 (14.5)
15 (12.0)
Moderate
230 (66.5)
144 (65.2)
86 (68.8)
Poor
69 (19.9)
45 (20.3)
24 (19.2)
TNM stage
0.035
I
88 (25.4)
65 (29.4)
23 (18.4)
II
116 (33.5)
75 (33.9)
41 (32.8)
III
142 (41.1)
81 (36.7)
61 (48.8)
CRP (mg/L)
<0.001
≤ 10.5
250 (72.3)
219 (99.1)
31 (24.8)
> 10.5
96 (27.7)
2 (0.9)
94 (75.2)
ALB (g/L)
0.037
≤ 40.5
179 (51.7)
105 (47.5)
74 (59.2)
> 40.5
167 (48.3)
116 (52.5)
51 (40.8)
PALB (mg/L)
<0.001
≤ 248
161 (46.5)
81 (36.7)
80 (64.0)
> 248
185 (53.5)
140 (63.3)
45 (36.0)
CAR
<0.001
≤ 0.3
272 (78.6)
221 (100)
51 (40.8)
> 0.3
74 (21.4)
0 (0)
74 (59.2)
ESCC: esophageal squamous cell carcinoma; CRP: C-reactive protein; PALB: prealbumin; ALB: albumin; CPR: C-reactive protein to prealbumin ratio; CAR: C-reactive protein to albumin ratio; TNM: tumor, node, metastasis.
