C-Reactive Protein to Prealbumin Ratio (CPR): A Novel Inflammatory-Nutritional Prognostic Factor for Predicting Cancer-Specific Survival (CSS) and Overall Survival (OS) in Patients with Resectable Esophageal Squamous Cell Carcinoma
Table 2
Univariate and multivariate analyses of CSS in ESCC patients.
Univariate analysis
P-value
Multivariate analysis
P-value
HR (95% CI)
HR (95% CI)
Age (years)
0.584
≤ 60
1.000
> 60
0.930 (0.717-1.206)
Gender
0.530
Female
1.000
Male
1.105 (0.809-1.510)
Tumor length (cm)
0.001
≤ 3.0
1.000
> 3.0
1.634 (1.208-2.211)
Tumor location
0.845
Upper
1.000
Middle
1.160 (0.624-2.156)
0.638
Lower
1.197 (0.644-2.222)
0.569
Vessel invasion
0.003
Negative
1.000
Positive
1.636 (1.187-2.255)
Differentiation
0.075
Well
1.000
Moderate
1.247 (0.834-1.864)
0.282
Poor
1.660 (1.045-2.638)
0.032
CRP (mg/L)
<0.001
≤ 10.5
1.000
> 10.5
1.896 (1.450-2.479)
ALB (g/L)
0.002
≤ 40.5
1.000
> 40.5
0.669 (0.517-0.867)
PALB (mg/L)
<0.001
≤ 248
1.000
> 248
0.613 (0.474-0.792)
CPR
<0.001
0.008
≤ 0.03
1.000
1.000
> 0.03
2.116 (1.634-2.739)
1.630 (1.135-2.342)
CAR
<0.001
0.052
≤ 0.3
1.000
> 0.3
1.485 (0.997-2.212)
Adjuvant therapy
1.000
0.329
No
1.149 (0.870-1.517)
Yes
TNM stage
<0.001
<0.001
I
1.000
1.000
II
1.804 (1.237-2.631)
0.002
1.628 (1.111-2.387)
0.012
III
3.067 (2.150-4.373)
<0.001
2.559 (1.786-3.667)
<0.001
BMI (kg/m2)
≥ 20
1.000
<0.001
1.000
<0.001
< 20
2.006 (1.551-2.595)
1.877 (1.444-2.440)
ESCC: esophageal squamous cell carcinoma; CRP: C-reactive protein; PALB: prealbumin; ALB: albumin; CPR: C-reactive protein to prealbumin ratio; CAR: C-reactive protein to albumin ratio; TNM: tumor, node, metastasis; BMI: body mass index; CI: confidence interval; HR: hazard ratio.
