The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review

Figure 1

The diagram showed LRP5/6 that consists of YWTD repeats and three O-linked sugar domain (LA) repeats. It was recognised as cell surface endocytic receptors in the LDL-receptor family which bind and internalise extracellular ligands for degradation by lysosomes (adapted from Bovenshen, 2010).