Yttrium-90-Labeled Anti-Glypican 3 Radioimmunotherapy Halts Tumor Growth in an Orthotopic Xenograft Model of Hepatocellular Carcinoma

Figure 2

Plot of serum AFP concentration compared to tumor bioluminescence by IVIS imaging in tumor-bearing mice. Serum AFP concentration in mice 6 weeks after orthotopic HepG2-Red-FLuc xenograft implantation is highly correlated with tumor bioluminescence by IVIS imaging, indicating that AFP excretion by HepG2 orthotopic xenografts is dependent on tumor size.