Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage

Table 4

Univariate and multivariate logistic regression analyses of acute exacerbation of IPF.

(a) Univariate logistic regression analysis

	HR	95%CI	p value
Age	1.064	0.980-1.155	0.137
ECOG (0-1 vs. 2-3)	1.620	0.466-5.628	0.448
FVC % pred	0.961	0.900-1.026	0.236
GAP stage (Stage I vs. Stage II/III)	5.167	1.390-19.210	0.014
SCLC stage (Limited vs. Extensive)	2.374	0.718-7.852	0.157
Smoking, Pack-years	1.026	0.997-1.055	0.081
Emphysema	0.612	0.112-3.334	0.570

(b) Multivariate logistic regression analysis

	HR	95%CI	p value
GAP stage (Stage I vs. Stage II/III)	5.851	1.453-23.565	0.013
SCLC stage (Limited vs. Extensive)	1.948	0.510-7.442	0.329
Smoking, Pack-years	1.028	0.998-1.060	0.066
Emphysema	0.345	0.043-2.766	0.316

Abbreviations: ECOG, Eastern Cooperative Oncology Group; FVC, forced vital capacity; GAP, gender, age, and physiology; IPF, idiopathic pulmonary fibrosis; SCLC, small cell lung cancer.