Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity

Figure 3

Epithelial-mesenchymal transition (EMT) of gastrointestinal carcinoma with plasmacytoid morphology. The “epithelial-type carcinoma with plasmacytoid morphology” is characterized by membrane positivity for E-cadherin (a) and β-catenin (b). In the “mesenchymal-type carcinoma with plasmacytoid morphology”, loss of E-cadherin (c-right) and β-catenin (d-right) or nuclear translocation of β-catenin (e) can be seen. Vimentin positivity (f) is also characteristics of carcinomas with EMT transition.

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