TP53 Mutations Promote Immunogenic Activity in Breast Cancer

Figure 4

Immune signatures significantly correlate with p53-regulated pathways, genes, and proteins in BC. (a) Immune signatures likely positively correlate with the p53-mediated pathways that show higher activity in TP53-mutated BCs than in TP53-wildtype BCs. (b) Immune signatures positively correlate with EGFR, CDH3, and TFRC, and their protein products that are upregulated in TP53-mutated BCs, while they negatively correlate with ESR1, GATA3, and PCR, and their protein products that are downregulated in TP53-mutated BCs relative to TP53-wildtype BCs.

(a)

(b)