The effect of mTORC1 on NRF2 expression and activation. The activation of mTORC1 promotes the transcriptional activation of eIF4F. The eIF4F complex can induce NRF2 mRNA expression. NRF2 translocation into the nucleus is restricted because of its attachment to KEAP1. However, mTORC1 activation can induce the phosphorylation of p62 (at serine 351) and promote NRF2 translocation into the nucleus through p62-mediated KEAP1 degradation.