mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

Figure 4

A strategic proposal for enhancing tumor sensitivity to radiation via inhibiting mTOR signaling. Activated mTORC1 signaling in tumors might effectively eliminate radiation-induced ROS through promoting antioxidant mechanisms. However, inhibiting mTOR signaling might attenuate the antioxidant KEAP1-NRF2 pathway. Therefore, blockade of mTOR signaling in tumors might be an alternative strategy to increase tumor susceptibility to radiation.