mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

Table 1

Glutathione synthesis-related proteins in the poor prognosis of tumor patients.

	Type of cancer	Level	Effects	Ref.
Glutathione peroxidase (GPX)	Breast cancer	High	Metastasis↑	[80]
			Patient mortality↑
	Bladder cancer	High	Recurrence↑	[91]
	Oral squamous cell carcinoma	High	Metastasis↑	[92]
			Poor survival↑
	Gastric carcinoma	High	Metastasis↑	[108]
			Progression↑
	Hepatocellular carcinoma	High	Poor prognosis↑	[109]
			Recurrence↑
Glutathione reductase (GR)	Glioblastoma	High	Drug resistance↑	[81]
			Poor survival↑
Glutamate-cysteine ligase (GLC)	Hepatocellular carcinoma	High	Progression↑	[110]
			Drug resistance↑
			Poor survival↑
	Breast cancer	High	Drug resistance↑	[111]
	Melanoma	High	Malignancy↑	[112]
	Lung adenocarcinoma	High	Recurrence↑	[113]
			Poor survival↑
Glutaminase 1 (GLS1)	Colorectal cancer	High	Metastasis↑	[114]
			Poor prognosis↑
			Poor survival↑
	Hepatocellular carcinoma	High	Malignancy↑	[115]
			Poor prognosis↑
			Cancer stem cells
	Breast cancer	High	In HER2-type↑	[116]
SLC7A11 (xCT)	Colorectal cancer	High	Recurrence↑	[117]
			Poor survival↑
	Non-small-cell lung carcinoma	High	Poor survival↑	[118]
	Glioma	High	Poor survival↑	[119]
	Hepatocellular carcinoma	High	Poor survival↑	[120]
	Breast cancer	High	Poor prognosis↑	[121]