Journal of Oncology / 2019 / Article / Tab 1

Review Article

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

Table 1

Glutathione synthesis-related proteins in the poor prognosis of tumor patients.

Type of cancerLevelEffectsRef.

Glutathione peroxidase (GPX)Breast cancerHighMetastasis↑[80]
Patient mortality↑
Bladder cancerHighRecurrence↑[91]
Oral squamous cell carcinomaHighMetastasis↑[92]
Poor survival↑
Gastric carcinomaHighMetastasis↑[108]
Progression↑
Hepatocellular carcinomaHighPoor prognosis↑[109]
Recurrence↑

Glutathione reductase (GR)GlioblastomaHighDrug resistance↑[81]
Poor survival↑

Glutamate-cysteine ligase (GLC)Hepatocellular carcinomaHighProgression↑[110]
Drug resistance↑
Poor survival↑
Breast cancerHighDrug resistance↑[111]
MelanomaHighMalignancy↑[112]
Lung adenocarcinomaHighRecurrence↑[113]
Poor survival↑

Glutaminase 1 (GLS1)Colorectal cancerHighMetastasis↑[114]
Poor prognosis↑
Poor survival↑
Hepatocellular carcinomaHighMalignancy↑[115]
Poor prognosis↑
Cancer stem cells
Breast cancerHighIn HER2-type↑[116]

SLC7A11 (xCT)Colorectal cancerHighRecurrence↑[117]
Poor survival↑
Non-small-cell lung carcinomaHighPoor survival↑[118]
GliomaHighPoor survival↑[119]
Hepatocellular carcinomaHighPoor survival↑[120]
Breast cancerHighPoor prognosis↑[121]