Human Papillomavirus and Anal Cancer: Prevalence, Genotype Distribution, and Prognosis Aspects from Midwestern Region of Brazil
Table 2
HPV DNA and anal cancers, according to sociodemographic and clinical/pathological characteristics.
Variables
HPV + (n)
%
HPV − (n)
%
OR (CI 95%)
Gender
Female
40
78.4
11
21.6
0.01
3.18 (1.19–8.48)
Male
16
53.3
14
46.7
Age at diagnosis (years)
<61 years
26
68.4
12
31.6
0.89
0.93 (0.36–2.41)
≥61 years
30
69.8
13
30.2
Marital status
Single
24
64.9
13
35.1
Married
29
72.5
11
27.5
0.46
0.70 (0.26–1.84)
Smoker
Yes
15
68.2
7
31.8
0.97
0.98 (0.33–2.86)
No
37
68.5
17
31.5
Alcohol consumption
Yes
11
64.7
6
35.3
0.63
0.76 (0.24–2.39)
No
41
70.7
17
29.3
Lesion location
Anal canal
38
64.4
21
35.6
0.55
0.60 (0.11–3.26)
Anal border
6
75.0
2
25.0
Both
12
85.7
2
14.3
Histological type
SCC
37
88.1
5
11.9
0.0001
9.51 (2.96–30.50)
Adenocarcinoma
14
43.8
18
56.2
Others
5
71.4
2
28.6
Size of tumor
T1-2
41
70.6
17
29.3
0.44
1.50 (0.52–4.25)
T3-4
14
63.6
8
36.4
Lymph node metastasis
Yes
14
66.7
7
33.3
0.77
0.85 (0.29–2.48)
No
42
70.0
18
30.0
Distant metastases
Yes
5
71.4
2
28.6
1.00
1.13 (0.20–6.25)
No
51
68.9
23
31.1
Death
Yes
30
66.7
15
33.3
0.59
0.76 (0.29–2.00)
No
26
72.2
10
27.8
SCC: squamous cell carcinoma. Others: basaloid carcinoma, neuroendocrine, and cloacogenic; number of patients with data not informed that they were positive for HPV: marital status 3; smoking 4; alcohol consumption 4; and size of tumor not specified 1. Statistically significant values for .
