Pregnancy Hypertension and a Commonly Inherited IGF1R Variant (rs2016347) Reduce Breast Cancer Risk by Enhancing Mammary Gland Involution
Table 1
Participant characteristics by HDP statusa.
Characteristic
HDP+ N = 76
HDP− N = 115
valueb
N (%)
Age at biopsy (years)
0.82
≤39
26 (34.2)
36 (31.2)
40–49
24 (31.6)
33 (28.7)
50–59
18 (23.7)
29 (25.2)
≥60
8 (10.5)
17 (14.8)
Age at menarche (years)
0.23
≤11
19 (25.0)
19 (16.5)
12
18 (23.7)
40 (34.8)
13
25 (32.9)
31 (27.0)
≥14
14 (18.4)
25 (21.7)
Parity
0.38
1
17 (22.4)
26 (22.6)
2
36 (47.4)
64 (55.7)
≥3
23 (30.2)
25 (21.7)
Age at first birth (years)
0.89
≤24
25 (32.9)
35 (30.4)
25–29
26 (34.2)
43 (37.4)
≥30
25 (32.9)
37 (32.2)
BMI (kg/m2)
0.00
≤24.9
12 (15.8)
45 (39.1)
25–29.9
22 (29.0)
32 (27.8)
≥30
42 (55.2)
38 (33.1)
Family historyc
0.81
Yes
21 (27.6)
30 (26.1)
No
55 (72.4)
85 (73.9)
Rs2016347 genotype
0.83
GG
18 (23.7)
24 (20.9)
GT
37 (48.7)
61 (53.0)
TT
21 (27.6)
30 (26.1)
Gail 5-year risk scores
0.44
Mean
1.50%
1.69%
aAll participants identify as non-Hispanic white. b value is the chi-squared value for differences in distribution between HDP+ and HDP− participants. cAt least one first-degree relative with breast cancer.
