Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients

Table 1

Minor allele frequencies among breast cancer patients and healthy controls and the HWEc p value of ABC gene polymorphisms.

Gene	SNP ID	SNP position	Cases (n = 222)				Controls (n = 218)
			MA	MAF	HWE	MA	MAF	HWE
								p-value
					p-value
ABCC1	rs35626	16076758	T	0.38	0.3	T	0.41	0.12
	rs35628	16077249	G	0.1	0.049	G	0.11	0.27
	rs4148351	16076711	T	0.16	0.037	T	0.2	N/A
ABCC2	rs2273697	99804058	A	0.25	N/A	A	0.24	0.089
	rs3740065	99845936	G	0.23	N/A	G	0.21	0.066
	rs717620	99782821	T	0.12	0.75	T	0.13	0.38
ABCB1	rs1045642	87509329	T	0.35	0.025	T	0.43	0.026
	rs1128503	87550285	A	0.36	0.039	A	0.44	0.074
	rs2032582	87531302	T	0.03	0.4591	T	0.01	0.615
ABCG2	rs2231142	88131171	T	0.04	0.552	T	0.04	0.572

Chromosome positions are based on NCBI Human Genome Assembly Build. MA: minor allele. MAF: minor allele frequency. HWE: Hardy–Weinberg equilibrium. N/A: not applicable.