Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients

Table 2

Association of the investigated ABCC1, ABCC2, ABCB1, and ABCG2 SNPs and breast cancer (BC).

Gene	SNP ID	Allelic and Genotypic Frequencies in Cases and Controls
		Allele/Genotype	Cases	Controls	P-value	Chi-square
			(n = 222)	(n = 218)
ABCC1	rs35626	G	283(0.65)	256 (0.59)	0.073	3.214
		T	155 (0.35)	180 (0.41)
		GG	95 (0.43)	81(0.37)	0.216	3.063
		GT	93 (0.42)	94(0.43)
		TT	31 (0.14)	43 (0.2)
	rs35628	A	394 (0.9)	388 (0.89)	0.788	0.072
		G	44 (0.1)	46 (0.11)
		AA	180(0.82)	175(0.81)	0.820	0.395
		AG	34(0.16)	38(0.18)
		GG	5(0.02)	4(0.02)
	rs4148351	C	369(0.84)	346(0.8)	0.082	3.021
		T	69 (0.16)	88 (0.2)
		CC	160 (0.73)	138 (0.64)	0.068	5.374
		CT	49 (0.22)	70(0.32)
		TT	10 (0.05)	9(0.04)
ABCC2	rs2273697	G	332(0.75)	331(0.76)	0.778	0.079
		A	108 (0.25)	103 (0.24)
		AA	13 (0.06)	17(0.08)	0.412	1.773
		GA	82 (0.37)	69(0.32)
		GG	125 (0.57)	131(0.6)
	rs3740065	A	341(0.77)	345(0.79)	0.478	0.503
		G	101(0.23)	91(0.21)
		AA	131(0.59)	141(0.65)	0.285	2.51
		AG	79(0.36)	63(0.29)
		GG	11(0.05	14(0.06)
	s717620	C	387(0.88)	377(0.87)	0.285	2.51
		T	55(0.12)	57 (0.13)
		CC	170(0.77)	165(0.76)	0.928	0.149
		CT	47(0.21)	47(0.22)
		TT	4(0.02)	5(0.02)
ABCB1	rs1045642	C	288(0.65)	248(0.57)	0.012	6.364
		T	152(0.35)	186(0.43)
		CC	102(0.46)	79(0.36)	0.063	5.499
		CT	84(0.38)	90(0.41)
		TT	34(0.15)	48(0.22)
	rs1128503	A	278(0.64)	242(0.56)	0.016	5.791
		G	158(0.36)	192(0.44)
		AA	36(0.17)	49(0.23)	0.074	5.189
		GA	86(0.39)	94(0.43)
		GG	96(0.44)	74(0.34)
	rs2032582	A	144(0.33)	174(0.43)	0.035	6.668
		C	284(0.65)	252(0.58)
		T	12(0.03)	6(0.01)
		AA	29(0.13)	41(0.19)	1e-8	44.386
		CA	82(0.37)	90(0.42)
		CC	97(0.44)	79(0.37)
		TA	49(0.02)	2(0.0093)
		TC	8(0.04)	4(0.02)
ABCG2	rs2231142	T	17(0.04)	16(0.04)	0.902	0.015
		G	425 (0.96)	418 (0.96)
		GG	204(0.92)	201(0.93)	0.899	0.016
		GT	17(0.08)	16(0.07)

P value <0.05 was considered as significant.