Research Article

CD133 Is Associated with Increased Melanoma Cell Survival after Multikinase Inhibition

Figure 9

ABCG2 siRNA knockdown in BAK melanoma cells is sensitized to targeted therapies and increases drug sensitivity of BAK cells. (a) Immunoblot analysis of ABCG2 and beta-actin following siRNA-mediated CD133 knockdown. (b) Cell viability (%) of CD133-depleted siRNA knockdown BAK cells compared to scrambled control after exposure to D, T, and the combination treatment.