Accuracy of mRNA HPV Tests for Triage of Precursor Lesions and Cervical Cancer: A Systematic Review and Meta-Analysis

Table 3

Accuracy of Aptima for detection of Cervical Intraepithelial Neoplasia (CIN) in histopathological, compared to a DNA hrHPV test (Hybrid Capture 2), in the same sample. Outcome: CIN1- vs. CIN2+.

	Aptima; % (IC 95%)	Hybrid Capture 2; % (IC 95%)
Sensitivity	93.9 (92.8-94.8)	94.3 (93.3-95.2)
Specificity	61.7 (60.6-62.7)	51.3 (50.2-52.4)
DOR	15.96 (10.14-25.17)	12.55 (92.33-17.07)
AUC	0.90 (0.80-1)	0.91 (0.88-0.95)
TP	2,184	2,206
FP	3,243	4,092
FN	143	133
TN	5,216	4,312
N total	10,786	10,743

CIN: cervical intraepithelial neoplasia; CI: Confidence interval; DOR: diagnostic odds ratio; AUC: area under the curve; TP: true positive; FP: false positive; FN: false negative; TN: true negative.
Small differences between Aptima e HC2 total is due to losses in three studies in HC2 sample: Clad et al., 2011, Monsonego et al., 2011 and Reid et al., 2015.