TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study

Table 3

Genotype frequencies of TDG gene polymorphisms in male colorectal cases and controls.

SNP	Variant	Patients Cases	Controls	OR	CI	χ^2 Value	p-value
rs4135050	TT	32 (0.55)	60 (0.63)	Ref
	TA	21 (0.36)	27 (0.28)	1.458	0.714–2.977	1.08	0.29910
	AA	5 (0.09)	8 (0.08)	1.172	0.354–3.879	0.07	0.79493
	TA+AA	26 (0.45)	35 (0.37)	1.393	0.717–2.707	0.96	0.32771
	T	85 (0.73)	147 (0.77)	Ref
	A	31 (0.27)	43 (0.23)	1.247	0.731–2.126	0.66	0.41728
rs1882018	CC	35 (0.60)	60 (0.63)	Ref
	CT	18 (0.31)	27 (0.29)	1.143	0.552–2.366	0.13	0.71901
	TT	5 (0.09)	8 (0.08)	1.071	0.325–3.531	0.01	0.90971
	CT+TT	23 (0.40)	35 (0.37)	1.127	0.576–2.204	0.12	0.72787
	C	88 (0.76)	147 (0.77)	Ref
	T	28 (0.24)	43 (0.23)	1.088	0.631–1.875	0.09	0.76200
rs4135066	CC	3 (0.05)	7 (0.07)	Ref
	CT	21 (0.36)	30 (0.32)	1.633	0.378–7.054	0.44	0.50827
	TT	34 (0.59)	58 (0.61)	1.368	0.332–5.643	0.19	0.66390
	CT+TT	55 (0.95)	88 (0.93)	1.458	0.362–5.877	0.28	0.59390
	C	27 (0.23)	44 (0.23)	Ref
	T	89 (0.77)	146 (0.77)	0.993	0.575–1.716	0.001	0.98108
rs3751209	GG	36(0.62)	44 (0.46)	Ref
	GA	15 (0.26)	45 (0.47)	0.407	0.196–0.847	5.92	0.01495
	AA	7 (0.12)	6 (0.07)	1.426	0.440–4.622	0.35	0.55296
	GA+AA	22 (0.38)	51 (0.54)	0.527	0.271–1.027	3.58	0.05840
	G	87 (0.75)	133 (0.70)	Ref
	A	29 (0.25)	57 (0.30)	0.778	0.461–1.311	0.89	0.34517
rs1866074	AA	12 (0.20)	12 (0.13)	Ref
	AG	23 (0.40)	40 (0.42)	0.575	0.222–1.487	1.32	0.25137
	GG	23 (0.40)	43 (0.45)	0.535	0.208–1.379	1.70	0.19227
	AG+GG	46 (0.80)	83 (0.87)	0.554	0.230–1.333	1.77	0.18362
	A	47 (0.41)	64 (0.34)	Ref
	G	69 (0.59)	126 (0.66)	0.746	0.463–1.202	1.45	0.22776
rs4135113	GG	45 (0.78)	75 (0.79)	Ref
	GA	9 (0.16)	18 (0.19)	0.833	0.345–2.012	0.16	0.68491
	AA	4 (0.07)	2 (0.02)	3.333	0.587–18.937	2.05	0.15266
	GA+AA	13 (0.22)	20 (0.21)	1.083	0.492–2.387	0.04	0.84257
	G	99 (0.85)	168 (0.88)	Ref
	A	17 (0.15)	22 (0.12)	1.311	0.664–2.588	0.61	0.43370