Age-Related Changes in the Fraction of Cervical Intraepithelial Neoplasia Grade 3 Related to HPV Genotypes Included in the Nonavalent Vaccine

Table 2

Distribution of HPV genotypes included in the nonavalent HPV vaccine according to age groups in CIN3.

HPV genotypes	<35 years n (%)	35–44 years n (%)	≥45 years n (%)	value
	Sample size (79)	Sample size (75)	Sample size (50)
HPV-16	57 (72.2)	54 (72.0)	27 (54.0)	0.047
HPV-18	5 (6.3)	6 (8.0)	4 (8.0)	0.697
HPV-31	2 (2.5)	7 (9.3)	3 (6.0)	0.303
HPV-33	9 (11.4)	5 (6.7)	1 (2.0)	0.044
HPV-45	2 (2.5)	2 (2.7)	4 (8.0)	0.148
HPV-52	1 (1.3)	2 (2.7)	1 (2.0)	0.713
HPV-58	3 (3.8)	1 (1.3)	3 (6.0)	0.624

Using the Cochran–Armitage test for trend. HPV: human papillomavirus; CIN: cervical intraepithelial neoplasia.