Review Article

Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies

Table 1

The list of the genes renamed within the last years and the most commonly used abbreviations.

Renamed Genes

Previous NamePrevious DescriptionCurrent NameCurrent Description

AML1Acute Myeloid Leukemia 1RUNX1Runt Related Transcription Factor 1

Ang-1Angiopoietin-1ANGPT1Angiopoietin 1

BRN3ABrain-3APOU4F1POU Class 4 Homeobox 1

CD11cCD11c AntigenITGAXIntegrin Subunit Alpha X

CD133CD133 AntigenPROM1Prominin 1

ELA2Elastase-2ELANEElastase, Neutrophil Expressed

ETOProtein ETORUNX1T1RUNX1 Translocation Partner 1

EVI1Ecotropic Viral Integration Site 1MECOMMDS1 And EVI1 Complex Locus

FLJ14054Homo sapiens cDNA FLJ14054 fis, clone HEMBB1000240NPR3Natriuretic Peptide Receptor 3

IL8Interleukin-8CXCL8C-X-C Motif Chemokine Ligand 8

MADH1Mothers Against Decapentaplegic Homolog 1SMAD1SMAD Family Member 1

MDR1Multidrug Resistance Protein 1ABCB1ATP Binding Cassette Subfamily B Member 1

MEL1MDS1/EVI1-Like Gene 1PRDM16PR/SET Domain 16

MLLMixed Lineage LeukemiaKMT2ALysine Methyltransferase 2A

MLLT2Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 2AFF1AF4/FMR2 Family Member 1

MLLT4Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To, 4AFDNAfadin, Adherens Junction Formation Factor

NICALNEDD9-Interacting Protein With Calponin Homology And LIM DomainsMICAL1Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 1

OPNOsteopontinSPP1Secreted Phosphoprotein 1

PTRFPolymerase I And Transcript Release FactorCAVIN1Caveolae Associated Protein 1

PU.1Hematopoietic Transcription Factor PU.1SPI1Spi-1 Proto-Oncogene

Abbreviations

AMLacute myeloid leukemia

ALLacute lymphoblastic leukemia

APLacute promyelocytic leukemia

BMbone marrow

CBFcore binding factor

circRNAscircular RNAs

CLLchronic lymphocytic leukemia

CMLchronic myeloid leukemia

CN-AMLcytogenetically normal AML

CRcomplete remission

DEGsdifferentially expressed genes

DFSdisease-free survival

FLT3-ITDFLT3-internal tandem duplication

FABFrench-American-British (classification system)

GEPgene expression profiling

HHHedgehog

HSCshematopoietic stem cells

HSPCshematopoietic stem-progenitor cells

lncRNAslong noncoding RNAs

LSCsleukemic stem cells

MDSmyelodysplastic syndromes

MRDminimal residual disease

MSCmesenchymal stem cells

NGSnext generation sequencing

NK-AMLnormal karyotype AML

NPMc+NPM-cytoplasmic positive

OSoverall survival

PBperipheral blood

PBMCsperipheral blood mononuclear cells

SAGEserial analysis of gene expression

snoRNAssmall nucleolar RNAs

TCGAthe Cancer Genome Atlas

TEstransposable elements

WBCwhite blood cell

WHOWorld Health Organization