IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis

Figure 5

Effect of IL-2 on cell-cycle phases. HeLa and INBL cells were incubated with and without 100 IU/ml of IL-2 for 48 hours to determine cell-cycle phases. (a, b) A significant arrest in G1 phase was observed after IL-2 treatment for 48 hours in INBL cell line. After inducing G1 arrest by treating cells with 100 IU of IL-2 for 48 hours, the medium containing IL-2 was removed, and fresh culture medium supplemented with 10% FBS was added. The cells were cultured further for 24 and 48 hrs. (c, d) HeLa and INBL cells reentry to the cell cycle. .

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