Journal of Oncology / 2019 / Article / Tab 2 / Review Article
Casein and Peptides Derived from Casein as Antileukaemic Agents Table 2 Effect of caseins in haematopoietic cells in vitro .
Casein Biological functions Ref Bovine α -, β -, and κ -caseins Inhibit the proliferation of the 32D myeloid mice cell line and induce the expression of cfms and FcgRIIB1 and FcgRIIB22 receptors [41 ] Bovine α -, β -, and κ -caseins Inhibit the proliferation of WEHI-3 leukaemic cells but induces cell differentiation, the expression of GM-CSF and its receptor GM-CSFR, as well as the isoforms FcgRIIB1 and FcgRIIB22 [42 ] Human α S1-casein Activates the secretion of pro-inflammatory cytokines such as GM-CSF, IL-1β , and IL-6 in human monocytes via the MAPK-p38 signalling pathway [43 , 44 ] Human α S1-casein Enhances the mitogen-stimulated proliferation of murine splenic T lymphocytes [45 ] Human α S1-casein Pro-inflammatory properties throughout the TLR4 pathway [46 ] Human α S1-casein May constitute an autogenous stimulus to uphold chronic TLR4 pathway inflammation [47 ] Bovine β -casein Enhances mitogen-induced proliferation of bovine T and B lymphocytes in a dose-dependent manner [48 ] Bovine κ -casein CGP Suppresses murine and rabbit lymphocyte proliferation induced by mitogens [45 ]
cfms, M-CSF receptor; IL-1β , interleukin 1β ; IL-6, interleukin 6; CGP, caseinoglycopeptide; MAPK-p38, mitogen-activated protein kinase p38.