Identification of Cell-Free Circulating MicroRNAs for the Detection of Early Breast Cancer and Molecular Subtyping

Table 2

ROC curve of deregulated miRNAs by molecular subtype.

Molecular Subtype	miRNAs	Fc	Sensitivity	Specificity	Th	AUC
Luminal A	hsa-miR-18b-5p	-1.58	67%	83%	2.54	0.82
	hsa-miR-23a-3p	1.91	67%	100%	4.12	0.89
	hsa-miR-25-3p	3.56	92%	83%	3.08	0.92
	hsa-miR-487b-5p	-2.27	100%	92%	3.32	0.94
	hsa-miR-30e-3p	-2.05	100%	83%	2.85	0.92
	hsa-miR-122-5p	3.03	83%	83%	5.39	0.86
	hsa-miR-132-3p	-2.29	100%	75%	2.57	0.86
	hsa-miR-196a-5p	2.24	92%	83%	3.17	0.83
	hsa-miR-301b-5p	1.54	83%	83%	3.13	0.83
	hsa-miR-335-5p	1.69	75%	83%	2.75	0.85
	hsa-miR-376a-3p	2.20	83%	83%	3.53	0.83
	hsa-miR-526b-5p	-1.60	67%	83%	3.04	0.83
	hsa-miR-543	-1.84	67%	92%	3.64	0.89
	hsa-miR-548ah-5p	1.69	75%	83%	3.34	0.84
	hsa-miR-627-5p	-2.24	83%	92%	4.12	0.89
	hsa-miR-873-3p	2.11	100%	83%	3.13	0.90
	hsa-miR-887-5p	-1.75	83%	83%	3.21	0.87
	hsa-miR-3614-5p	-1.58	83%	75%	3.41	0.81
	hsa-miR-6503-5p	-1.76	67%	92%	3.33	0.83
Luminal B	hsa-miR-146a-5p	-1.67	83%	84%	3.20	0.83
	hsa-miR-188-5p	-1.60	83%	83%	3.79	0.83
	hsa-miR-203a-5p	1.87	75%	100%	2.64	0.80
	hsa-miR-502-5p	1.69	75%	100%	2.91	0.83
	hsa-miR-548ar-5p	1.90	67%	100%	5.05	0.81
	hsa-miR-548a-5p	1.85	83%	83%	2.71	0.85
	hsa-miR-548ah-5p	1.75	67%	83%	3.69	0.81
	hsa-miR-128-1-5p	-1.53	100%	75%	2.64	0.80
Luminal B HER2+	hsa-miR-25-3p	2.73	75%	83%	3.32	0.82
	hsa-miR-378d	-2.65	67%	92%	4.31	0.83
	hsa-miR-379-5p	1.87	67%	83%	3.13	0.85
	hsa-miR-449b-5p	-1.65	67%	83%	3.10	0.83
	hsa-miR-582-5p	-2.05	67%	75%	3.84	0.80
	hsa-miR-615-3p	1.78	67%	100%	2.96	0.83
	hsa-miR-887-5p	-1.74	67%	92%	3.71	0.82
	hsa-miR-888-5p	-1.62	83%	75%	3.38	0.86
	hsa-miR-933	1.53	83%	83%	2.47	0.89
	hsa-miR-1302	-1.54	83%	75%	3.27	0.80
HER2+	hsa-miR-548ar-5p	3.07	100%	77%	5.24	0.97
	hsa-miR-584-3p	-1.53	100%	100%	4.45	1.00
	hsa-miR-615-3p	-1.62	100%	84%	4.20	0.94
	hsa-miR-1283	-2.24	100%	100%	6.09	1.00

Accuracy of deregulated miRNAs with ROC curve 0.8. Fc: fold-change; Th: threshold; AUC: area under the curve.