Tubal Origin of “Ovarian” Low-Grade Serous Carcinoma: A Gene Expression Profile Study

Figure 4

Validation of differentially expressed proteins by IHC. The top panel represents H&E stains, while the second to fourth panels represent immunohistochemical stains with the antibodies against OVGP1, WT-1, and FNC1, respectively. The findings are correlated with the gene expression profiles. OVGP1 and WT-1 are positively expressed in FT, OEI, SC, SBT, and LGSC, but negative in OSE. In contrast, FNC1 is expressed only in OSE, not in other tested samples. Original magnification: 100X. FT, fallopian tube; OEI, ovarian epithelial inclusions; SC, serous cystadenoma; SBT, serous borderline tumor; LGSC, low-grade serous carcinoma; OSE, ovarian surface epithelia.