Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype

Table 1

Summary of notch receptors-related processes and treatments in TNBC.

Notch receptor	Process	Refs	Treatment	Studies	Refs
Notch1	Tumor growth	[59–61]
	Mitochondrial metabolism	[60, 80]	mAbs	Preclinical	[156]
	Regulation of cancer stem cells	[64, 65, 68]	mAbs (+chemotherapeutic agents)	Preclinical	[64, 66, 156, 159]
	Drug resistance	[67–70, 73, 75]	GSI + chemotherapeutic agents	Preclinical and clinical	[74, 151–153]
	Invasion and metastasis	[59, 71, 73]
Notch2	Tumor growth	[87, 88]
	Regulation of cancer stem cells	[84, 85]	mAbs	Preclinical	[157]
	Invasion and metastasis	[84, 85]
Notch3	Tumor growth	[92, 93]
	Angiogenesis	[97, 98]	mAbs	Preclinical and clinical	[93, 157, 161]
	Drug resistance	[110, 111]
	Invasion and metastasis	[103, 104, 107]
Notch4	Regulation of cancer stem cells	[125–128]	mAbs	Preclinical	[126]
	Invasion and metastasis	[117, 118]	GSI	Preclinical	[118]

Abbreviations. mAbs: monoclonal antibodies; GSI: γ-secretase inhibitor.