Live Cell Imaging Supports a Key Role for Histone Deacetylase as a Molecular Target during Glioblastoma Malignancy Downgrade through Tumor Competence Modulation

Figure 4

iHDAC treatment radiosensitizes U87-MG cells that, in turn, increase mitochondrial activity. U87-MG cells were irradiated (A, B), and MTT assay showed a significant increase in absorbance in the DMSO group at 24 h and 48 h after ionizing irradiation (C) and did not show significant differences, at the same time points, in iHDAC-treated cells (C). Cell counting using trypan blue at 24 h, 48 h, and 72 h time points after irradiation showed a significant decrease in cellular viability between the DMSO and iHDAC groups (D). ; ; ; .