AURKA rs8173 G>C Polymorphism Decreases Wilms Tumor Risk in Chinese Children
Table 1
Association between AURKA gene polymorphisms and Wilms tumor susceptibility.
Genotype
Cases (N = 143)
Controls (N = 531)
Crude OR (95% CI)
Adjusted OR (95% CI)b
rs1047972 C>T (HWE = 0.598)
CC
110 (76.92)
412 (77.59)
1.00
1.00
CT
30 (20.98)
110 (20.72)
0.89 (0.57–1.39)
0.613
0.89 (0.57–1.39)
0.622
TT
3 (2.10)
9 (1.69)
1.09 (0.29–4.08)
0.898
1.10 (0.29–4.10)
0.891
Additive
0.945
1.05 (0.71–1.55)
0.809
1.04 (0.71–1.54)
0.834
Dominant
33 (23.08)
119 (22.41)
0.866
1.04 (0.67–1.61)
0.865
1.03 (0.66–1.60)
0.889
Recessive
140 (97.90)
522 (98.31)
0.746
1.24 (0.33–4.65)
0.747
1.22 (0.33–4.59)
0.764
rs2273535 T>A (HWE = 0.701)
TT
66 (46.15)
234 (44.07)
1.00
1.00
TA
65 (45.45)
234 (44.07)
0.82 (0.57–1.16)
0.263
0.82 (0.57–1.17)
0.265
AA
12 (8.39)
63 (11.86)
0.56 (0.29–1.08)
0.084
0.56 (0.29–1.08)
0.085
Additive
0.502
0.88 (0.67–1.17)
0.377
0.88 (0.67–1.17)
0.374
Dominant
77 (53.85)
297 (55.93)
0.656
0.92 (0.63–1.33)
0.656
0.92 (0.63–1.33)
0.659
Recessive
131 (91.61)
468 (88.14)
0.241
0.68 (0.36–1.30)
0.244
0.68 (0.35–1.29)
0.237
rs8173 G>C (HWE = 0.272)
GG
71 (49.65)
196 (36.91)
1.00
1.00
GC
54 (37.76)
263 (49.53)
0.51 (0.35–0.73)
0.0003
0.50 (0.35–0.73)
0.0002
CC
18 (12.59)
72 (13.56)
0.62 (0.35–1.08)
0.090
0.61 (0.35–1.08)
0.088
Additive
0.018
0.74 (0.56–0.98)
0.033
0.75 (0.56–0.99)
0.040
Dominant
72 (50.35)
335 (63.09)
0.006
0.59 (0.41–0.86)
0.006
0.60 (0.42–0.88)
0.008
Recessive
125 (87.41)
459 (86.44)
0.762
0.92 (0.53–1.60)
0.762
0.92 (0.53–1.61)
0.781
OR, odds ratio; CI, confidence interval; HWE, Hardy–Weinberg equilibrium. aχ2 test for genotype distributions between Wilms tumor patients and controls; badjusted for age and gender.
