Research Article
2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90
Figure 2
(a) The A375 cell viability graph after incubation with FA within the concentration range between 1 mM and 31.25 μM for 24 hours. (b) The viability of melanoma A375 cells is inhibited after treatment with 10 μM 2-ME, 1 mM FA, and combination of both for 24 hours. The cell viability was determined by MTT assay. Values are the mean ± SE of six independent experiments (N = 6 repeats). and vs. control. Statistical significance was determined by a one-way ANOVA analyses followed by Tukey’s multiple comparison test and unpaired t test.
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