GATA1 Promotes Gemcitabine Resistance in Pancreatic Cancer through Antiapoptotic Pathway
Figure 1
GATA1 is overexpressed in PDAC and confers resistance to gemcitabine in PDAC patients. (a) Representative immunohistochemical staining of GATA1 in 86 pairs of PDAC tissues and adjacent normal pancreas tissues. Scale bar: 50 μm. (b) H scores of GATA1 expression between normal and cancer tissues were compared by Mann-Whitney U test. (c) Representative Western blot assay of tumor tissues and paired adjacent normal tissues. Paired t test was used to compare GATA1 expression between normal tissues and cancer tissues (n = 30). (d) Kaplan-Meier survival curves for overall survival and recurrence-free survival of 172 PDAC patients according to the relative expression of GATA1. (e) Kaplan-Meier survival curves of patients with (n = 119) or without gemcitabine treatment (n = 53).