Journal of Oncology / 2019 / Article / Tab 1

Research Article

Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997–2017 in China National Cancer Center

Table 1

Clinicopathological characteristics by tumor location.

Total GCPGCDGCP Value
N (%)N (%)N (%)

Age at diagnosis (years)
 Mean (SD)58.5 (11.4)61.5 (10.0)56.4 (11.9)<0.001
 Younger (≤35)590 (3.7)86 (1.3)504 (5.2)
 Middle-aged (36-65)10,842 (67.3)4,026 (62.1)6,816 (70.7)
 Older (≥66)4,685 (29.1)2,366 (36.5)2,319 (24.1)<0.001
Gender
 Male4,171 (25.9)5,374 (82.9)6,574 (68.2)
 Female11,948 (74.1)1,105 (17.1)3,066 (31.8)<0.001
Smoking status
 Never smokers9,289 (57.6)3,065 (47.3)6,224 (64.6)
 Smokers6,621 (41.1)3,352 (51.7)3,269 (33.9)<0.001
 Current smokers4,634 (28.8)2,210 (34.1)2,424 (25.2)
 Ex-smokers1,987 (12.3)1,142 (17.6)845 (8.8)<0.001
Alcohol consumption
 Never drinkers10,398 (64.5)3,716 (57.4)6,682 (69.3)
 Drinkers5,496 (34.1)2,699 (41.7)2,797 (29.0)<0.001
 Current drinkers4,752 (29.5)2,416 (37.3)2,336 (24.2)
 Ex-drinkers744 (4.6)283 (4.4)461 (4.8)<0.001
BMI (kg/m2)
 <18.51,066 (6.6)380 (5.9)686 (7.1)
 18.5-22.96,097 (37.8)2,301 (35.5)3,796 (39.4)
 23-27.46,576 (40.8)2,760 (42.6)3,816 (39.6)
 ≥27.52,028 (12.6)909 (14.0)1,119 (11.6)<0.001
H. pylori
 No1,247 (7.7)437 (6.7)625 (6.5)
 Yes956 (5.9)331 (5.1)810 (8.4)
 Unknown13,916 (86.3)5,711 (88.2)8,205 (85.1)<0.001
Pathologic T stage
 T0+Tis58 (0.4)14 (0.2)44 (0.5)
 T12,491 (15.5)596 (9.2)1,895 (19.7)
 T21,376 (8.5)441 (6.8)935 (9.7)
 T33,019 (18.7)1,640 (25.3)1,379 (14.3)
 T46,288 (39.0)2,573 (39.7)3,715 (38.5)
 TX2,887 (17.9)1,215 (18.8)1,672 (17.3)<0.001
Pathologic N stage
 N04,538 (28.2)1,623 (25.1)2,915 (30.2)
 N12,281 (14.1)983 (15.2)1,298 (13.5)
 N22,417 (15.0)1,081 (16.7)1,336 (13.9)
 N33,759 (23.3)1,489 (23.0)2,270 (23.6)
 NX3,124 (19.4)1,303 (20.1)1,821 (18.9)<0.001
Pathologic M stage
 M013,629 (84.6)5,555 (85.7)8,074 (83.8)
 M11,883 (11.7)651 (10.1)1,232 (12.8)<0.001
pTNM
 052 (0.3)13 (0.2)39 (0.4)
 I2,989 (18.5)825 (12.7)2,164 (22.5)
 II2,112 (13.1)929 (14.3)1,183 (12.3)
 III7,354 (45.6)3,272 (50.5)4,082 (42.3)
 IV1,883 (11.7)651 (10.1)1,232 (12.8)<0.001
Lauren classification
 Intestinal2,390 (14.8)1,215 (18.8)1,175 (12.2)
 Diffuse2,202 (13.7)555 (8.6)1,647 (17.1)
 Mixed1,486 (9.2)592 (9.1)894 (9.3)
 Unknown10,041 (62.3)4,117 (63.5)5,924 (61.5)<0.001
Type of gastrectomy
 Gastrectomy13,190 (81.8)5,260 (81.2)7,930 (82.3)
 No surgery2,929 (18.2)1,219 (18.8)1,710 (17.7)0.068
Surgical Margin
 Negative12,457 (77.3)4,950 (76.4)7,507 (77.9)
 Positive on the proximal margin183 (1.1)91 (1.4)92 (1.0)
 Positive on the distal margin197 (1.2)74 (1.1)123 (1.3)
 Positive on the proximal and distal margin46 (0.3)12 (0.2)34 (0.4)0.002
HER2 score
 0 (-)2,850 (17.7)1,037 (16.0)1,813 (18.8)
 1 (+)2,620 (16.3)971 (15.0)1,649 (17.1)
 2 (++)1,082 (6.7)466 (7.2)616 (6.4)
 3 (+++)522 (3.2)275 (4.2)247 (2.6)
 Unknown9,045 (56.1)3,730 (57.6)5,315 (55.1)<0.001
Linitis plastica
 No15,670 (97.2)6,286 (97.0)9,384 (97.3)
 Yes110 (0.7)31 (0.5)79 (0.8)0.024
Borrmann classification
 Borrmann I1,160 (7.2)714 (11.0)446 (4.6)
 Borrmann II4,605 (28.6)1,926 (29.7)2,679 (27.8)
 Borrmann III3,843 (23.8)1,574 (24.3)2,269 (23.5)
 Borrmann IV981 (6.1)347 (5.4)634 (6.6)
 Unknown1,807 (11.2)696 (10.7)1,111 (11.5)<0.001

GC, gastric cancer; PGC, proximal gastric cancer; DGC, distal gastric cancer; SD, standard deviation.

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