Antibiotics Improve the Treatment Efficacy of Oxaliplatin-Based but Not Irinotecan-Based Therapy in Advanced Colorectal Cancer Patients

Table 3

Hematological toxicity of antibiotic-treated and antibiotic-untreated groups in oxaliplatin- and irinotecan-based therapy.

Group	Oxaliplatin-based therapy			Irinotecan-based therapy
	Antibiotic-treated (n = 67)	Antibiotic-untreated (n = 53)		Antibiotic-treated (n = 53)	Antibiotic- untreated (n = 47)
Leukopenia	9 (13.4)	1 (1.9)	0.042	11 (20.8)	5 (10.6)	0.156
Neutropenia	22 (32.8)	5 (9.4)	0.016	20 (37.7)	6 (12.8)	0.045
Anemia	7 (10.4)	5 (9.4)	0.854	2 (3.8)	2 (4.3)	0.751
Thrombocytopenia	3 (4.5)	5 (9.4)	0.281	5 (9.4)	4 (8.5)	0.881
Elevation of bilirubin	2 (3.0)	2 (3.8)	0.812	2 (3.8)	1 (2.1)	0.564
Elevation of AST or ALT	7 (10.4)	5 (9.4)	0.854	5 (9.4)	6 (12.8)	0.441
Elevation of creatinine	0 (0.0)	1 (1.9)	0.2	0 (0.0)	0 (0.0)	1

ALT: alanine aminotransferase; AST: aspartate aminotransferase. was calculated using Pearson’s chi-square test.