Research Article

Computational Identification of Tumor Suppressor Genes Based on Gene Expression Profiles in Normal and Cancerous Gastrointestinal Tissues

Table 1

The 17 tumor suppressor genes (TSGs) and their associated pathways.

Entrez IDSymbolNamePathway

11181TREHTrehalase (brush-border membrane glycoprotein)Starch and sucrose metabolism
10235RASGRP2RAS guanyl releasing protein 2 (calcium and DAG-regulated)Chemokine signaling pathway
MAPK signaling pathway
8174MADCAM1Mucosal vascular addressin cell adhesion molecule 1Cell adhesion molecules (CAMs)
Intestinal immune network for IgA production
6366CCL21Chemokine (C-C motif) ligand 21Chemokine signaling pathway
Cytokine-cytokine receptor interaction
2939GSTA2Glutathione S-transferase alpha 2Drug metabolism-cytochrome P450
Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
2538G6PCGlucose-6-phosphatase, catalytic subunitAdipocytokine signaling pathway
Galactose metabolism
Glycolysis/gluconeogenesis
Insulin signaling pathway
Starch and sucrose metabolism
2208FCER2Fc fragment of IgE, low affinity II, receptor for CD23Hematopoietic cell lineage
653BMP5Bone morphogenetic protein 5TGF-beta signaling pathway