Prognostic Factors in Patients with Rhabdomyosarcoma Using Competing-Risks Analysis: A Study of Cases in the SEER Database
Table 2
Univariate analysis of prognostic factors in patients with rhabdomyosarcoma.
Variables
Classification
Cancer-specific mortality (%)
Non-cancer-specific mortality (%)
1 year
3 years
5 years
1 year
3 years
5 years
Total
15.7
35.3
39.5
<0.001
4.7
7.4
8.7
<0.001
Age
<19
8.3
26.3
31.3
<0.001
0.5
1.4
2.0
<0.001
≥19
26.1
47.9
51.1
10.7
16.0
18.2
Year
1986–1995
16.4
34.9
39.7
0.967
2.5
4.8
5.8
0.001
1996–2005
15.7
35.8
39.6
4.7
6.6
7.4
2006–2015
15.6
34.9
39.4
5.2
8.8
10.5
Race
White
15.1
33.8
37.9
0.022
5.0
8.0
9.2
0.022
Black
17.7
40.0
43.3
4.7
6.7
8.0
Other
17.3
38.3
45.5
2.8
4.8
5.7
Sex
Male
17.1
35.9
40.6
0.269
6.3
9.2
10.3
0.011
Female
14.6
34.7
38.6
3.5
6.1
7.4
Marital
Married
27.1
48.1
51.1
<0.001
10.3
16.8
19.3
<0.001
Unmarried
11.0
30.6
35.5
1.5
2.7
3.5
DSW
31.7
46.8
47.7
21.6
29.3
31.8
Site
Favorable
12.9
28.7
32.0
<0.001
4.0
6.4
7.1
<0.001
Unfavorable
17.1
38.5
43.2
5.1
7.9
9.5
Historic stage
Localized
5.8
16.1
19.1
0.000
2.8
5.8
7.9
0.841
Regional
11.8
30.1
34.7
4.7
7.0
8.1
Distant
30.0
60.0
65.2
6.7
9.6
10.1
Tumor size
<5
6.6
19.7
22.4
0.000
2.1
4.9
6.5
0.013
5–10
11.6
33.2
38.0
4.1
6.2
7.5
≥10
26.2
47.4
51.9
7.4
10.3
11.6
Other
20.8
43.0
47.7
5.9
9.0
9.7
Laterality
Not a paired site
14.6
34.6
38.1
<0.001
4.5
7.2
8.2
<0.001
Left
12.9
29.1
34.3
3.4
5.5
7.2
Right
17.4
38.0
42.1
5.4
8.3
9.5
HS
RMS
26.7
44.8
48.4
0.000
10.3
15.5
18.2
0.000
Embryonal
9.4
23.1
26.7
1.5
2.3
2.5
Alveolar
14.7
47.0
53.3
2.3
4.6
5.9
Pleomorphic
26.2
43.4
45.4
14.0
20.4
23.1
Other
11.3
24.3
29.0
3.8
6.6
7.5
RS
NRS
20.2
39.7
43.3
<0.001
5.9
8.9
10.0
<0.001
WRS
7.5
26.9
32.3
2.6
4.8
6.3
IRS
5.6
27.8
33.3
0.0
0.0
0.0
Surgery
Yes
11.7
27.2
31.6
0.000
4.5
7.4
9.0
0.053
No/unknown
22.5
48.7
52.7
5.1
7.6
8.2
Chemotherapy
Yes
14.2
34.8
39.4
0.172
2.4
4.5
5.4
0.000
No/unknown
23.7
37.6
39.9
16.8
22.5
26.0
Radiotherapy
Yes
10.5
32.6
37.6
<0.001
2.7
4.8
5.7
<0.001
None/unknown
22.6
38.7
41.9
7.5
10.9
12.5
DSW: divorced and separated and widowed; RMS: rhabdomyosarcoma; HS: histology subtype; RS: radiation sequence with surgery; NRS: no radiation and/or cancer-directed surgery; WRS: radiation prior to surgery, radiation after surgery, and radiation before and after surgery; IRS: intraoperative radiation and intraoperative rad with other rad before/after surgery.
