Research Article
High Expression of the Long Noncoding RNA SNHG15 in Cancer Tissue Samples Predicts an Unfavorable Prognosis of Cancer Patients: A Meta-Analysis
Table 1
Characteristics of the studies included in the meta-analysis.
| | Study | Year | Country | Cancer type | Detection method | Internal control | Cutoff | Total sample | Expression | Tumor stage | Metastasis analysis | Outcome | HR estimation | NOS score | | High | Low |
| | Zhang et al. [18] | 2016 | China | HCC | qRT-PCR | GAPDH | Median | 152 | 77 | 75 | I–IV | N/A | OS | SC | 8 | | Chen et al. [19] | 2016 | China | GC | qRT-PCR | GAPDH | Median | 106 | 53 | 53 | I–IV | DM/LNM | OS/RFS | Reported | 7 | | Gou et al. [21] | 2018 | China | PC | qRT-PCR | GAPDH | Median | 171 | 82 | 89 | I–IV | LNM | OS | SC | 8 | | Du et al. [22] | 2018 | China | RCC | qRT-PCR | β-Actin | Median | 96 | 47 | 52 | T1–T4 | N/A | OS | SC | 7 | | Wu et al. [23] | 2018 | China | TC | qRT-PCR | GAPDH | Median | 92 | 50 | 42 | I–IV | LNM | OS | Reported | 9 | | Cui et al. [24] | 2018 | China | NSCLC | qRT-PCR | GAPDH | FC | 55 | 28 | 27 | I–IV | LNM | OS | SC | 7 | | Dong et al. [25] | 2018 | China | NSCLC | qRT-PCR | GAPDH | Median | 49 | 23 | 26 | I–IV | LNM | OS/RFS | SC | 7 | | Jin et al. [26] | 2018 | China | NSCLC | qRT-PCR | GAPDH | FC | 35 | 20 | 15 | I–III | LNM | OS | SC | 8 | | Kong and Qiu [15] | 2018 | China | BC | qRT-PCR | GAPDH | Median | 58 | 29 | 29 | I–IV | LNM | OS | SC | 7 | | Huang et al. [27] | 2019 | China | CRC | qRT-PCR | GAPDH | Median | 91 | 46 | 45 | I–IV | DM/LNM | OS | SC | 8 | | Qu et al. [28] | 2019 | China | OC | qRT-PCR | GAPDH | Median | 182 | 73 | 109 | I–IV | N/A | OS/RFS | SC | 8 |
|
|
HCC: hepatocellular carcinoma; GC: gastric cancer; PC: pancreatic ductal cancer; RCC: renal cell carcinoma; TC: thyroid carcinoma; NSCLC, non-small-cell lung cancer; BC: breast cancer; CRC: colorectal cancer; EOC: epithelial ovarian cancer; qRT-PCR: quantitative reverse transcription PCR; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; FC: fold change; LNM: lymph node metastasis; DM: distant metastasis; N/A: not available; OS: overall survival; SC: survival curve; RFS: recurrence -free survival; HR: hazard ratio; and NOS: Newcastle–Ottawa Scale.
|
