Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer

Table 8

Summary data on the tumor microvessel morphology in squamous cervical cancer.

	Normal microvessels	DCs with a normal endothelial lining	DCs with a weak expression of CD34	DCs of contact type	Capillaries in the solid tumor component	Atypical dilated capillaries	The structures with a partial endothelial lining	Lymphatic vessels in lymphoid and polymorphic cell infiltrates
Localization	In intra- and peritumoral stroma	In intra- and peritumoral stroma	Mainly in peritumoral stroma	Mainly in intratumoral stroma	In the solid tumor component	In intra- and peritumoral stroma	Mainly in peritumoral stroma	Mainly in peritumoral stroma
Diameter (μm)	19.7 ± 10.0	101.9 ± 52.2	59.4 ± 29.6	48.7 ± 10.5	Collapsed	109.7 ± 43.9	—	85.2 ± 33.3
Shape	Regular	Regular and irregular	Regular	Regular	Linear	Irregular	Irregular	Regular
Contours	Smooth	Smooth	Smooth	Smooth	Smooth	Uneven	Uneven	Smooth
Arrangement of the endothelial cells	Normal	Normal	Normal	Normal	Normal	Chaotic	Chaotic	Normal
The severity of CD34 expression	Intensively	Intensively	Weakly	Moderately	Intensively	Intensively	Intensively	Moderately
Podoplanin staining	Some positive	Some positive	Negative	Negative	Negative	Some positive	Some positive	All positive
Content	Erythrocytes, white blood cells	Erythrocytes, white blood cells	Often absent	Absent or white blood cells	—	Absent, erythrocytes, white blood cells	Absent or tumor mass	Lymphocytes and other white blood cells
Tumor emboli in the lumen	Rarely	Rarely	Rarely	Rarely	Rarely	Often	Often	Rarely
CD34-positive cells in the lumen	Rarely	Rarely	Absent	Absent	Absent	Often	Often	Absent