An Early Myeloma Bone Disease Model in Skeletally Mature Mice as a Platform for Biomaterial Characterization of the Extracellular Matrix

Figure 1

Detection of MOPC315.BM.Luc cells in 26-week-old BALB/c mice following inoculation. (a) BLI images of ventral and lateral views of a MOPC315.BM.Luc- and a PBS-injected mouse at increasing days after inoculation. (b) BLI signals (total flux in photons⁻¹) of one control and ten MM mice at days after inoculation (median, interquartile range). (c) Typical femoral injection site (white arrow) in a 3D microCT reconstruction at day 21.

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