An Early Myeloma Bone Disease Model in Skeletally Mature Mice as a Platform for Biomaterial Characterization of the Extracellular Matrix

Figure 3

3D renderings of high-resolution microCT and PCE-CT for bone ultrastructural characterization of femora injected with PBS (a, b) versus MOPC315.BM.Luc cells (c, d) at day 21. (a, c) MicroCT images of ventral and dorsal views of one representative femur of PBS-injected (a) and MM-injected (c) bones. (b, d) Synchrotron PCE-CT 3D reconstructions of the same bones scanned by microCT reveal higher resolution detail in both ventral and dorsal regions just above the condyles.

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