Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva for Breast Cancer Diagnosis

Figure 4

Comparison of the area under the 1433 cm⁻¹ and 1302.9 cm⁻¹ wavenumber region between the three study groups. (a) Average original spectra highlighting the 1433–1302.9 cm⁻¹ region for breast cancer (red line), benign breast disease (black line), and control saliva (blue line). (b) Scatter plot of the 1433 cm⁻¹ and 1302.9 cm⁻¹ region for breast cancer (red), benign breast disease (black), and control saliva (blue). The line represents the mean, and the error bars (whiskers) represent the standard error of the mean (SEM) (, pairwise comparison of groups via the Mann–Whitney test). ROC curves made from area under the 1433 cm⁻¹ and 1302.9 cm⁻¹ region for (c) breast cancer vs. control and (d) breast cancer vs. benign breast disease. Results about area under the curve (AUC), value, cutoff, sensitivity, and specificity are being shown near the ROC curve. Statistically significant differences are represented by ().

(a)

(b)

(c)

(d)