Tumor Primary Location May Affect Metastasis Pattern for Patients with Stage IV NSCLC: A Population-Based Study

Table 2

Multivariate logistic regression analyses to evaluate the risk factors for different metastasis patterns.

Variables	Bone metastasis		Brain metastasis		Liver metastasis		Lung metastasis
	OR (95% CI)	P	OR (95% CI)		OR (95% CI)	P	OR (95% CI)
Age		<0.001		<0.001		0.060		<0.001
<65	Reference
≥65	0.860 (0.810–0.914)	<0.001	0.581 (0.544–0.621)	<0.001	0.927 (0.857–1.003)	0.060	1.222 (1.143–1.307)	<0.001
Race		<0.001		0.088		0.239		<0.001
White	Reference
Black	0.834 (0.764–0.911)	<0.001	0.911 (0.827–1.003)	0.057	0.913 (0.814–1.023)	0.116	1.011 (0.920–1.112)	0.817
Others	0.991 (0.893–1.101)	0.871	1.051 (0.938–1.178)	0.390	0.944 (0.821–1.085)	0.415	1.277 (1.141–1.429)	<0.001
Sex		<0.001		<0.001		0.064		0.028
Female	Reference
Male	1.188 (1.119–1.261)	<0.001	0.886 (0.829–0.946)	<0.001	1.077 (0.996–1.164)	0.064	0.929 (0.870–0.992)	0.028
Histology		<0.001		<0.001		0.794		<0.001
Adenocarcinoma	Reference
Squamous cell carcinoma	0.663 (0.619–0.709)	<0.001	0.501 (0.461–0.543)	<0.001	1.012 (0.928–1.103)	0.794	0.849 (0.789–0.914)	<0.001
T stage		<0.001		<0.001		0.206		<0.001
T1	Reference
T2	0.847 (0.765–0.937)	0.001	0.980 (0.878–1.094)	0.721	1.059 (0.921–1.219)	0.421	1.408 (1.210–1.637)	<0.001
T3	0.815 (0.734–0.904)	<0.001	0.843 (0.752–0.944)	0.003	1.131 (0.982–1.303)	0.088	4.400 (3.808–5.086)	<0.001
T4	0.829 (0.750–0.917)	<0.001	0.794 (0.711–0.886)	<0.001	1.131 (0.986–1.297)	0.079	6.967 (6.048–8.024)	<0.001
N stage		<0.001		<0.001		<0.001		<0.001
N0	Reference
N1	1.279 (1.135–1.440)	<0.001	1.194 (1.047–1.361)	0.008	1.304 (1.110–1.532)	0.001	0.915 (0.796–1.050)	0.205
N2	1.314 (1.219–1.417)	<0.001	1.172 (1.078–1.273)	<0.001	1.510 (1.362–1.673)	<0.001	1.120 (1.030–1.218)	0.008
N3	1.308 (1.195–1.432)	<0.001	1.031 (0.932–1.141)	0.552	1.473 (1.304–1.664)	<0.001	1.654 (1.500–1.823)	<0.001
Primary site		0.009		0.003		0.723		0.008
Main bronchus	Reference
Upper lobe	1.141 (0.996–1.307)	0.057	1.229 (1.052–1.437)	0.010	0.939 (0.794–1.111)	0.463	1.182 (1.022–1.367)	0.024
Middle lobe	1.150 (0.956–1.384)	0.139	1.219 (0.990–1.501)	0.062	0.900 (0.709–1.141)	0.384	1.242 (1.015–1.519)	0.035
Lower lobe	1.222 (1.062–1.408)	0.005	1.127 (0.958–1.326)	0.149	0.948 (0.795–1.130)	0.550	1.299 (1.116–1.512)	0.001
Overlapping lesion	0.864 (0.639–1.169)	0.342	0.814 (0.573–1.157)	0.252	1.132 (0.792–1.618)	0.495	1.139 (0.840–1.544)	0.402