Review Article
Physical Properties of Nanoparticles That Result in Improved Cancer Targeting
Table 2
Effect of different NPs charges on tissue biodistribution: charged NPs are cleared rapidly by the immune system.
| Authors | NPs type | Charge | Uptake | Biodistribution |
| Xiao et al. [44] | PEG-micellar nanoparticles | Surface charge: high negative (<−10 mV) and high positive | High uptake by slightly negative charged NPs | All charged NPs cleared by the Kupffer cells | He et al. [45] | Polymeric NPs | Negative (−10 mV) neutral and positive charge (+35 mV) | High uptake of slight negative charged NP | Liver > spleen > lung > tumor > kidney > blood | Walczak et al. [46] | Polystyrene NPs 50 nm | Negative (−7, 7 mV) positive NPs and neutral | High uptake of negatively charged NPs than the neutral and positive one | Kidney > heart > stomach > small intestine | Verma et al. [47] | Encapsulated paclitaxel | Negative pectin NPs | — | (i) Major accumulation in liver > kidney > lung > spleen (ii) Tissue prolonged plasma retention |
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