Physical Properties of Nanoparticles That Result in Improved Cancer Targeting

Table 3

Effect of NPs coating on tissue biodistribution.

Authors	Nanoparticle	Coating added	Distribution
Zhang et al. [60]	Gold NPs	Zwitterionic polycarboxybetaine (PCB)	PK behavior was unchanged, no antiuricase detected, no anti-PCB antibodies detected
Rodriguez et al. [62]	160 nm nanobeads	CD47 “self” peptides	Prolonged drug circulation by delaying phagocytic clearance by the liver and spleen
Kreuter et al. [63]	poly(butyl cyanoacrylate) nanoparticles	Polysorbate 80	enhanced drug delivery beyond the blood-brain barrier
Parodi et al. [64]	Nanoporous silicon particles (NPS)	Membranes purified from white blood	Prolonged circulation time
Hu et al. [65]	Polymeric nanoparticles	Erythrocyte membrane	Prolonged circulation time
Romberg et al. [55]	Liposome	Poly(hydroxyethyl-L-asparagine) (PHEA)	Longer blood circulation times than PEG liposomes. The second injection less rapidly cleared from the circulation than the second dose of PEG liposomes
Lila et al. [66]	Liposome	Polyglycerol (PG)	Reduced effect of ABC when using polyglycerol compared to PEG