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| Author | Nanoparticle type | Nanoparticle size | Tumor type | Tumor penetration efficacy |
|
| Cabral et al. [71] | Drug loaded polymeric micelles | 30, 50, 70, 100 nm | Two cancer type (high and low permeable) | Only 30 nm penetrate poorly permeable cancer |
| Ezealisiji and Okorie [72] | Silver NPs | 22, 58, 76, 378 nm | Dermatological application | 22 nm exhibit the highest cumulative amount (penetration) |
| Arvizo et al. [77] | Gold NPs (without any surface modification) | 5, 10, 20 nm | Human umbilical vein endothelial cells | 20 nm Maximum effect anti-angiogenic effect(VFGF inhibition) |
| Peretz et al. [78] | Gold nanoparticles | 15, 30, 90, 150 nm | Head and neck cancer cells | 15 nm best binding capacity to cancer cells & 90 nm is optimal for cell targeting and tumor accumulation |
| Popović et al. [73] | Quantum dots | 12, 60, 125 nm | Melanoma in mouse | Rapid penetration for `12 nm NP |
| Sonavane et al. [27] | Gold nanoparticles | 15, 50, 100, 200 nm | Mice (different organ), intravenous administration | 15 nm wide organ distribution, only 15 and 50 nm pass blood brain barrier |
| Huang et al. [79] | PVP-coated iron oxide nanoparticles (PVP-IOs) | 37–120 nm | Hepatic lesion in mouse | 37 nm greatest cellular uptake |
| Hemant et al. [28] | Gold NPs | 1 to 125 nm (intravenous) | Different pore size | Rapid penetration for `12 nm NP |
| Huang et al. [80] | Gold nanoparticles (AuNPs) | 2, 6, 15 nm | Breast cancer cells | 2 and 6 nm Maximum tumor uptake and permeability. 2 & 6 nm found in nucleus and cytoplasm whereas 15 nm only in cytoplasm |
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